Ruvastin-5

Tablet
Generics: Rosuvastatin 5mg
Category : Prescription Medicines Availability : In Stock Company : Aristopharma Ltd.
You get 7% off in Prescription Medicines
Price

৳100.00

Required Prescription

Rosuvastatin is indicated in- Heterozygous Hyper - choles- terolemia (Familial and Non familial) Homozygous Hypercholesterolemia (Familial) Mixed Dyslipidemia (Fredrickson Type IIa and IIb) Primary prevention of cardiovascular disease

Ruvastin-5

Rosuvastatin could be a specific and competitive inhibitor of HMG-CoA reductase, the rate-limiting chemical that changes over 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a forerunner of cholesterol. Rosuvastatin produces its lipid-modifying impacts in two ways. To begin with, it increments the number of hepatic LDL receptors on the cell surface to upgrade take-up and catabolism of LDL. Moment, Rosuvastatin inhibits hepatic amalgamation of VLDL, which diminishes the overall number of VLDL and LDL particles.

 

Dosage

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

 

Administration

Rosuvastatin can be taken at any time of day, with or without meals.

 

Interaction

Remarkable drug interactions of Rosuvastatin are-

Cyclosporine: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.

Gemfibrozil: Combination should be avoided. If used together, the Rosuvastatin dose should be limited to 10 mg once daily.

Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be 10 mg once daily.

Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosuvastatin. INR should be monitored frequently until stable upon initiation or alteration of Rosuvastatin therapy.

Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

 

Contraindications

Rosuvastatin is contraindicated if-

Known hypersensitivity to product components

Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels

3.Pregnant women and women who may become pregnant

4.Nursing mothers

 

Side Effects

Rosuvastatin is for the most part well endured. The foremost visit unfavorable occasions thought to be related to Rosuvastatin were cerebral pain, myalgia, clogging, asthenia, stomach torment, and queasiness.

 

Pregnancy & Lactation

The safety of the drug in pregnant women has yet to be determined. Rosuvastatin is not known whether or whether it is excreted in human milk.

 

Precautions & Warnings

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness, or weakness. Rosuvastatin can be discontinued if signs or symptoms appear.

Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur. Liver enzymes should be monitored before and during treatment.

 

Therapeutic Class

It is unknown whether or not it is safe for pregnant women. Rosuvastatin isn't known if it's excreted in human milk.

 

Storage Conditions

Even if the canister appears to be empty, it should not be punctured, broken, or incinerated. Avoid storing in direct sunlight or in a hot environment. Keep it below 30°C. Keep your distance from the eyes. Keep your distance from youngsters.

 

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