Rupatadine is a non-sedative antagonist of histamine H1-receptors with a long half-life. It also inhibits platelet activating factor (PAF) (PAF). Histamine and PAF both cause broncho constriction, which increases vascular permeability and serves as a mediator in the inflammatory process.
Dosage & Administration
Adults and adolescents (aged 12 and up) should take 10 mg once a day. Rupatadine is a medication that can be taken with or without food.
Children between the ages of 2 and 11:
1 teaspoonful (5 ml) of the oral solution once daily, with or without food, for children weighing 25 kg or more.
1/2 teaspoonful (2.5 ml) oral solution once daily with or without food for children weighing 10 kg to less than 25 kg.
When taking Rupatadine 20 mg and ketoconazole or erythromycin at the same time, the systemic exposure is increased. When these drugs, as well as other inhibitors of the CYP3A4 isozyme, are taken together, rupatadine should be used with caution. When combined with statins, CNS depressants, or alcohol, rupatadine should be used with caution.
Intolerance to Rupatadine or any of the excipients.
Asthenia, dizziness, and drowsiness are all common symptoms. Uncommon: Increased appetite, arthralgia, back pain, dizziness, constipation, cough, diarrhea, dry throat, epistaxis, fever, gastrointestinal discomfort, increased risk of infection, irritability, malaise, myalgia, nasal dryness, nausea, oropharyngeal pain, rash, thirst, vomiting, weight gain Palpitations and tachycardia are uncommon.
Pregnancy & Lactation
There are no clinical studies on the effects of Rupatadine on a pregnant woman. Rupatadine should not be used by pregnant women unless the potential benefit outweighs the risk to the baby. There is no information on whether Rupatadine is excreted in breast milk. As a result, it should not be used during pregnancy or lactation.
Precautions & Warnings
Rupatadine should be used with caution in patients who have a known QT interval prolongation, uncorrected hypokalemia, or ongoing proarrhythmic conditions like clinically significant bradycardia or acute myocardial ischemia. In elderly patients, rupatadine should be used with caution (65 years and older).
Antihistamines that don't make you sleepy
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.