Rupamine

Tablet
Generics: Rupatadine Fumarate 10mg
Category : Prescription Medicines Availability : In Stock Company : The IBN SINA Pharmaceutical Industry Ltd.
You get 7% off in Prescription Medicines
Price

৳100.05

Required Prescription

Leaflet Rupatadine is used to treat the symptoms of seasonal and perennial allergic rhinitis, as well as urticaria.

Rupamine

Pharmacology 


Rupatadine is a non-sedative antagonist of histamine H1-receptors with a lengthy half-life. It also inhibits platelet activating factor (PAF) (PAF). Histamine and PAF both induce broncho constriction, which increases vascular permeability and serves as a mediator in the inflammatory process. Rupatadine has a stronger therapeutic impact than a solo antihistamine because of its dual mechanism of action. Rupatadine also inhibits mast cell degranulation produced by immunological and non-immune stimuli, as well as the production of cytokines, notably tumor necrosis factor alpha (TNF), in human mastocytes and monocytes. 

  

Dosage & Administration 


Adults and adolescents (over 12 years): The recommended dose is 10 mg once a day. Rupatadine may be taken with or without food. 
 
Children aged 2 to 11 year: 
 
 

  • Children weighing 25 kg or more: 1 teaspoonful (5 ml) of the oral solution once daily with or without food. 

  • Children weighing equal or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily with or without food. 

  

Interaction 


When using Rupatadine 20 mg with ketoconazole or erythromycin at the same time, the systemic exposure is increased. When these drugs, as well as other inhibitors of the CYP3A4 isozyme, are used together, rupatadine should be used with care. When used with statins, CNS depressants, or alcohol, rupatadine should be taken with care. 

Grapefruit and grapefruit juice should not be consumed at the same time as Rupatadine. 

  

Contraindications 


Intolerance to Rupatadine or any of the excipients. 

  

Side Effect 


Asthenia, dizziness, and sleepiness are all common symptoms. Uncommon: Increased appetite, arthralgia, back pain, dizziness, constipation, cough, diarrhea, dry throat, epistaxis, fever, gastrointestinal discomfort, increased risk of infection, irritability, malaise, myalgia, nasal dryness, nausea, oropharyngeal pain, rash, thirst, vomiting, weight gain Palpitations and tachycardia are uncommon. 

  

Pregnancy & Lactation 


There are no clinical studies on the effects of Rupatadine on a pregnant woman. Rupatadine should not be used by pregnant women unless the possible benefit outweighs the danger to the baby. There is no information on whether Rupatadine is excreted in breast milk. As a result, it should not be taken during breastfeeding unless the advantages to the mother outweigh the danger to the child. 

  

Precautions & Warnings 


Rupatadine should be taken with caution in individuals who have a known QT interval prolongation, uncorrected hypokalemia, or continuing proarrhythmic circumstances such clinically severe bradycardia or acute myocardial ischemia. In senior individuals, rupatadine should be administered with care (65 years and older). The use of Rupatadine 10 mg tablets in patients with compromised renal or liver function is currently not indicated due to a lack of clinical data. 

  

Therapeutic Class 


Non-sedating antihistamines 

  

Storage Conditions 


Protect against light and moisture by storing in a cool, dry area below 30°C. Keep out of children's reach. 

 

 

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