RTV 5

Tablet
Generics: Rosuvastatin 5mg
Category : Prescription Medicines Availability : In Stock Company : Delta Pharma Limited
You get 7% off in Prescription Medicines
Price

৳50.00

Required Prescription

Rosuvastatin is indicated in heterozygous Hyper- chole- sterolemia (Familial and Non familial) Homozygous Hypercholesterolemia (Familial) Mixed Dyslipidemia (Fredrickson Type IIa and IIb) Primary prevention of cardiovascular disease.

RTV 5

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

 

Administration & Dosage

Rosuvastatin can be taken with or without food, at any time of day.

Interaction

Remarkable drug interactions of Rosuvastatin are-


Cyclosporine: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.

Gemfibrosil: Combination should be avoided. If used together, Rosuvastatin dose should be limited to 10 mg once daily.

Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be to 10 mg once daily.

Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosuvastatin. INR should be monitored frequently until stable upon initiation or alteration of Rosuvastatin therapy.

 

Contraindications

Rosuvastatin is contraindicated if-


Known hypersensitivity to product components

Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels

Pregnant women and women who may become pregnant

Nursing mothers

 

Side Effects

Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

 

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.

 

Precautions & Warnings

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Rosuvastatin can be discontinued if signs or symptoms appear.

 

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

 

Storage Conditions

Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

 

 

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