Rovex 5

Tablet
Generics: Rosuvastatin 5mg
Category : Prescription Medicines Availability : In Stock Company : Orion Pharma Ltd.
You get 7% off in Prescription Medicines
Price

৳0.00

Required Prescription

The use of rosuvastatin is advised in the following situations: Hyper - cho- lesterolemia Heterozygous (Familial and Non familial) Hypercholesterolemia Homozygous (Familial) Dyslipidemia (Mixed) (Fredrickson Type IIa and IIb) Primary cardiovascular disease prevention

Rovex 5

HMG-CoA reductase is the rate-limiting enzyme that transforms 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. Rosuvastatin has two mechanisms for altering lipid levels. To begin, it boosts the amount of hepatic LDL receptors on the cell surface, which improves LDL absorption and degradation. Second, Rosuvastatin lowers the overall amount of VLDL and LDL particles by inhibiting VLDL production in the liver.

 

Dosage 

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

 

Administration

Rosuvastatin can be taken with or without food, at any time of day.

 

Interaction

The following are notable Rosuvastatin medication interactions:

Combination of cyclosporine with rosuvastatin enhances Rosuvastatin exposure. The daily dose of rosuvastatin should be kept at 5 mg.

Combination should be avoided with gemfibrosil. If used concurrently, the dose of rosuvastatin should be kept at 10 mg once a day.

The combination of lopinavir/ritonavir or atazanavir/ritonavir enhances Rosuvastatin exposure. The dose of rosuvastatin should be reduced to 10 mg once day.

Combination of coumarin anticoagulants increases the international normalized ratio (INR). Prior to commencing Rosuvastatin, make sure your INR is stable. When starting or stopping Rosuvastatin treatment, the INR should be checked often until it is stable.

Concurrent lipid-lowering therapies: Using fibrates and niacin products at the same time may raise the risk of skeletal muscle side effects.

 

Contraindications

If you're using rosuvastatin, you should avoid it if you have any of the following conditions:

Hypersensitivity to product components is known.

Liver disease, which might include unexplained chronic increases in liver enzymes, is one example.

levels of hepatic transaminase

Women who are pregnant or may become pregnant

Mothers who are breastfeeding

 

Side Effects

Rosuvastatin is well tolerated by most people. Headache, myalgia, constipation, asthenia, stomach discomfort, and nausea were the most common side effects linked to Rosuvastatin.

 

Pregnancy & Lactation

The safety of the drug in pregnant women has yet to be determined. Rosuvastatin is not known whether or whether it is excreted in human milk.

 

Precautions & Warnings

Combination of coumarin anticoagulants increases the international normalized ratio (INR). Prior to commencing Rosuvastatin, make sure your INR is stable. When starting or stopping Rosuvastatin treatment, the INR should be checked often until it is stable.

Concurrent lipid-lowering therapies: Using fibrates and niacin products at the same time may raise the risk of skeletal muscle side effects.

 

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

 

Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.

 

 

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