APT 75

Tablet
Generics: Clopidogrel Bisulphate 75mg
Category : Prescription Medicines Availability : In Stock Company : Sharif Pharmaceuticals Ltd.
You get 7% off in Prescription Medicines
Price

৳100.30

Required Prescription

APT Plus is indicated for the reduction of thrombotic events as follows: Recent MI, Recent Stroke or Established Peripheral Arterial Disease For patients with a history of recent myocardial infarction (MI), recent stroke or established peripheral arterial disease, APT Plus has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not) and other vascular death. Acute Coronary Syndrome: For patients with acute coronary syndrome (unstable angina/non-Q-wave MI) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or CABG. APT Plus has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI, or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.

APT 75

APT Plus is a fixed-dose combination drug containing Clopidogrel and Aspirin. Clopidogrel is an inhibitor of platelet aggregation. Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Clopidogrel also inhibits platelet aggregation induced by agonists other than ADP by blocking the amplification of platelet activation released by ADP. Aspirin is also an antiplatelet agent. Aspirin acts by causing irreversible inhibition of the cyclooxygenase enzyme, which leads to decreased formation of thromboxane A2 and ultimate inhibition of platelet aggregation.

 

Dosage & Administration of APT 75 Tablet

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease The recommended daily dose of APT Plus one tablet daily.

Acute Coronary Syndrome

For patients with acute coronary syndrome (unstable angina/non-Q-wave MI), APT Plus should be initiated with a 4 tablet stat loading dose and then continued at one tablet daily.

 

Interaction of APT 75 Tablet

Use caution with phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin and non-steroidal anti-inflammatory drugs.

 

Contraindications

  • Hypersensitivity to Clopidogrel
  • Hypersensitivity to Aspirin and/or non-steroidal anti-inflammatory agents
  • Recent history of gastrointestinal bleeding
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage, or bleeding disorders like hemophilia

 

Side Effects of APT 75 Tablet

The drug is generally well tolerated. Side effects that have been reported include abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting, constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash, palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia and vertigo.

 

Pregnancy & Lactation

Pregnancy: Adverse effects are increased in the mother and the fetus following chronic ingestion of Aspirin. Because of possible adverse effects on the neonate and the potential for increased maternal blood loss, APT Plus should be avoided during the last three months of pregnancy.

Lactation: APT Plus should be avoided in nursing mothers because of the possible risk of developing Reye's syndrome. Regular use of high doses of Aspirin could impair platelet function and produce hypoprothrombinemia in infants if neonatal vitamin K levels are low.

 

Precautions & Warnings

General: As with other anti-platelet agents, this combination drug should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an anti[1]platelet effect is not desired, APT Plus should be discontinued 7 days prior to surgery.

GI Bleeding: The combination of Clopidogrel and Aspirin prolongs the bleeding time. So, it should be used with caution in patients who have lesions with a propensity to bleed (such as ulcers).

Thrombotic thrombocytopenic purpura (TTP): TTP has been reported rarely following use of Clopidogrel.

Reye's syndrome: Reye's syndrome may develop in individuals who have chicken pox, influenza or flu symptoms. This combination is not recommended for use in patients with chicken pox, influenza or flu symptoms.

Nasal polyps or nasal allergies: The combination drug of Clopidogrel and Aspirin should be administered with caution in patients with nasal polyps or nasal allergies.

Hepatic or Renal Impairment: This should be avoided in patients with impaired hepatic and renal function. Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding.

 

Therapeutic Class

Anti-platelet drugs

 

Storage Conditions

Store at a cool and dry place, protected from light & moisture. Keep out of reach of children

 

 

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