Replet 75

Tablet
Generics: Clopidogrel Bisulphate 75mg
Category : Prescription Medicines Availability : In Stock Company : Healthcare Pharmaceuticals Limited
You get 7% off in Prescription Medicines
Price

৳110.00

Required Prescription

Acute coronary syndrome (ACS): suitable for reducing the occurrence of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS [Unstable angina (AI) / non-ST-segment elevation myocardial infarction (NSTEMI)] Rate. It is used to reduce the incidence of myocardial infarction and stroke in patients with ST-elevation myocardial infarction (STEMI) Recent MI, Recent Stroke, or Confirmed Peripheral Artery Disease: For patients with confirmed peripheral artery disease or recent myocardial infarction (MI), or a history of a recent stroke, it can reduce the incidence of myocardial infarction and stroke.

Replet 75

Clopidogrel is a prodrug. It inhibits platelet activation and aggregation by irreversibly binding its active metabolites to ADP P2Y12 receptors on platelets. Dose-dependent inhibition of platelet aggregation can be observed 2 hours after a single oral administration. A repeated daily dose of 75 mg inhibits ADP-induced platelet aggregation on the first day and the inhibition reaches a steady-state between the third and seventh day. 

Dosage & Administration

Acute Coronary Syndrome: In patients who need an antiplatelet effect within hours, initiate Replet with a single 300 mg (4 tablets) oral loading dose and then continue at 75 mg once daily. Initiating it without a loading dose will delay the establishment of an antiplatelet effect by several days.
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: 75 mg once daily orally without a loading dose.
It is given orally with or without food. 

Interactions

NSAIDs, warfarin, selective norepinephrine, and serotonin reuptake inhibitors (SSRIs, SNRIs): increase the risk of bleeding 
CYP2C19 inhibitors (omeprazole or esomeprazole): avoid simultaneous use of omeprazole or esomeprazole

Repaglinide (repaglinide will increase) and CYP8 the plasma concentration of repaglinide

Contraindications

Replet is contraindicated in the following situations: Allergic to any component of the drug or product. Active pathological bleeding, such as a peptic ulcer or intracranial hemorrhage.

Side Effects

Replet is usually a well-tolerated drug. 
Common side effects: bleeding, diarrhea, gastrointestinal discomfort, bleeding, skin reactions. 
Rare side effects: acquired hemophilia, anemia, angioedema, joint pain, arthritis, bone marrow disease.

Pregnancy

There are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only when clearly necessary. It is not clear whether clopidogrel is excreted in human milk. The importance of the drug to the mother should be considered and a decision made to stop breastfeeding or discontinue the drug.

Precautions

As with other antiplatelet agents, Clopidogrel or Aspirin should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, the drug should be discontinued 5 days prior to surgery. Clopidogrel and Aspirin prolong the bleeding time. Patients should be told that it might take them longer than usual to stop bleeding when they take drugs and that they should report any unusual bleeding to their physician.

Therapeutic Class

Anti-platelet drugs

Storage Conditions

Keep below 30°C temperature in a dry place. Protected from light. Do not freeze. Keep out of the reach of children.

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