Mecobalamin is the neurologically active form of vitamin
B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the
enzyme methionine synthase, which functions to transfer methyl groups for the
regeneration of methionine from homocysteine. In anaemia, it increases
erythrocyte production by promoting nucleic acid synthesis in the bone marrow
and by promoting maturation and division of erythrocytes.
Dosage &
Administration
Tablet: The
usual adult dosage is 500 mcg tablet three times daily. The dosage should be
adjusted according to the age of patient and the severity of symptoms.
Injection:
Peripheral neuropathies: The
usual adult dosage is 500 mcg Mecobalamin administered intramuscularly or
intravenously three times a week.The dosage should be adjusted according to the
age of patient and the severity of symptoms.
Megaloblastic anemia: The
usual adult dosage is 500 mcg Mecobalamin administered intramuscularly or
intravenously three times a week. After about two months of administration,
dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin
every one to three months as maintenance therapy
Interaction
Decreased GI tract absorption with neomycin,
aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations
with oral contraceptives. Reduced effects in anaemia with parenteral
chloramphenicol.
Contraindications
Hypersensitivity to any component of this product.
Side Effects
Generally Mecobalamin is well tolerated. However, a few
side effects like GI discomfort (including anorexia, nausea or diarrhea) &
rash may be seen after administration of Mecobalamin.
Pregnancy
& Lactation
Not recommended during pregnancy & lactation.
Precautions
& Warnings
The medicine should not be used for months if there is no
response at all after its use for a certain period of time.
Use in
Special Populations
Use in children: Not
recommended.
Therapeutic
Class
Drugs for Megaloblastic Anemia
Storage
Conditions
Oral: Store
at room temperature. Protect from moisture and light.
Parenteral: Store at room
temperature. Do not expose to direct light.
