Dorel 75

Tablet
Generics: Clopidogrel Bisulphate 75mg
Category : Prescription Medicines Availability : In Stock Company : GENERAL Pharmaceuticals Ltd.
You get 7% off in Prescription Medicines
Price

৳100.70

Required Prescription

Dorel is indicated for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.

Dorel 75

Clopidogrel is a prodrug. It inhibits platelet activation and aggregation by irreversibly binding its active metabolites to P2Y12 ADP receptors on platelets. Dose-dependent inhibition of platelet aggregation can be observed 2 hours after a single oral administration. A repeated daily dose of 75 mg inhibited ADP-induced platelet aggregation on the first day, and the inhibition reached a steady-state between days 3 and 7.

 

Dosage & Administration

Adults and elderly: The recommended dose of Clopidogrel is 75 mg once daily. It can be taken with or without food. No dosage adjustment is necessary for elderly patients or patients with renal disease.

Children and adolescents:  Safety and efficacy below the age of 18 years have not been established.

 

Interaction

The combination of Clopidogrel with NSAIDs may increase the risk of stomach and intestinal bleeding. At a high concentration in the blood, Dorel inhibits the activity of the enzyme which metabolizes Warfarin and increases the risk of bleeding due to over-thinning of the blood.

 

Contraindications

·         Hypersensitivity to the drug substance or any component of the

·         Active pathological bleeding such as a peptic ulcer or intracranial hemorrhage.

 

Side Effects

The tolerability of Dorel is similar to that of aspirin. Diarrhea, rash, or itching occur in approximately 1 in 20 persons taking Clopidogrel. Abdominal pain also occurs in about 1 in 20 persons, but it is less frequent than aspirin.

 

Pregnancy & Lactation

Pregnancy: There are no adequate studies of Clopidogrel in pregnant women. Therefore, it can be used in pregnancy if the physician determines that it is needed.

Nursing mothers: It is not known whether it appears in human breast milk. Because of the potential for side effects in the nursing infant, the physician must weigh the potential benefits and possible risks before prescribing this drug in nursing mothers.

 

Precautions & Warnings

As with other antiplatelet agents, Dorel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Dorel should be discontinued 7 days prior to surgery. Clopidogrel should be used with caution in patients who have ulcers or in hepatically impaired patients who may have bleeding diatheses.

 

Therapeutic Class

Anti-platelet drugs

 

Storage Conditions

Store in a cool (below 30º C) and dry place, away from light. Keep out of the reach of children.

 

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