Denosis 60

Generics: Denosumab 60mg/ml
Category : Prescription Medicines Availability : In Stock Company : Incepta Pharmaceuticals Ltd
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Required Prescription

In patients with bone metastases from solid tumors, prevention of skeletal events (pathological fractures, radiation to bone, spinal cord compression, or bone surgery).

Denosis 60

Pharmacology of Denosis Injection

Denosumab binds to RANKL, a transmembrane or soluble protein required for osteoclast development, function, and survival. Denosumab inhibits the activation of RANKL's receptor, RANK, on the surface of osteoclasts and precursors. Preventing the RANKL/RANK interaction decreases bone resorption and increases bone mass and strength in both cortical and trabecular bone by inhibiting osteoclast development, function, and survival.


Denosis Injection Dosage & Administration

Subcutaneous Injection: 120 mg once every 4 wk into thigh, abdomen or upper arm. Ca & vitamin D supplements should be given whilst undergoing treatment.



Denosumab (60 mg subcutaneous injection) had no effect on the pharmacokinetics of midazolam, which is metabolized by cytochrome P450 3A4 (CYP3A4), in postmenopausal osteoporosis patients, indicating that it should not affect the pharmacokinetics of drugs metabolized by this enzyme in this population.



Intolerance to denosumab or any of the excipients.


Denosis Injection Side Effects

Osteonecrosis of the Jaw, Dyspnoea, Hypocalcaemia, Hypophosphataemia (ONJ).


Pregnancy & Lactation

D is the pregnancy category. Although there is evidence of human fetal danger, the advantages of use in pregnant women may outweigh the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).


Precautions & Warnings

Pre-existing hypocalcaemia should be corrected before starting treatment. Jaw osteonecrosis is a condition in which the bone in the jaw begins to deteriorate (ONJ). Prior to treatment, perform an oral and dental examination using preventive dentistry. While on therapy, avoid invasive dental procedures and practice proper oral hygiene. Fractures of the femur that are not normal. Patients with severe renal impairment (CrCl 30 ml/min) or those on dialysis. Use with other denosumab-containing preparations. Lactation and pregnancy. Children


Therapeutic Class

Inhibiting bone resorption


Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Alternative brands for
Denosumab 60mg/ml